Multilayer-coated Implants for the Treatment of Existing Bone Infection in Direct Exchange Arthroplasty

摘要

Due to the current infection rate of orthopedic implants and the associated treatment involving six weeks of antibiotic therapy and two additional surgical operations, there is motivation to develop a one-stage re-implantation procedure. Here, we have fabricated polyelectrolyte multilayers incorporating gentamicin using the layer-by-layer deposition process for use as a device coating to fight an existing bone infection in a direct exchange process. This study has demonstrated that a layer-by-layer film can efficaciously fight a bone infection in vivo, and opens the door to the possibility of developing a multi-therapeutic film for optimized, synergistic treatment of pain, infection, and bone resorption.