A 'Multilayered' Approach to the Surface-Mediated Delivery of DNA: Designing Polyelectrolyte Multilayers to Achieve Tunable Release and Multi-Agent Delivery

摘要

We report the fabrication and characterization of ultrathin multilayered films that provide control over the release of DNA from surfaces. The approach is based on the synthesis of 'charge-shifting' cationic polymers, and permits the fabrication of surface coatings that enable (i) tunable control over the release of a single DNA construct and (ii) control over the release of two DNA constructs with separate and distinct release profiles.