Oscillatory flow in human arteries

摘要

Although genetic factors seem to be important, basic mechanisms related to arterial wall cell malfunction, which leads to atherosclerosis formation, depend on the blood flow properties. The present study correlates the factors simulating pulsatile blood flow in the human arteries (aortic arch) using patient-specific geometry. Using numerical techniques we examine the relation between time-Averaged Wall Shear Stress (AWSS) and Oscillatory Shear Index (OSI). The velocity vector oscillates and at the same time alters its direction in places with low AWSS values. Low AWSS and high OSI values do not always collocate. Regional differences between AWSS magnitude and OSI may answer the question as to where atherosclerotic lesions predominately develop and progress at specific aortic regions. This analysis gives information for deeper understanding of the atherosclerosis mechanisms.