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Bootstrap Analysis of Genetic Networks inferred by the Method Using LPMs

机译:使用LPM的方法推断的遗传网络的自举分析

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Recently, we proposed a genetic network inference method using linear programming machines (LPMs). As this method infers genetic networks by solving linear programming problems, its computational time is very short. However, generic networks inferred by the method using the LPMs often contain a large number of false-positive regulations. When we try to apply the inference method to actual problems, we must experimentally validate the inferred regulations. Therefore, it is important to reduce the number of false-positive regulations. To decrease the number of regulations we must validate, this study assigns confidence values to all of the possible regulations. For this purpose, we combine a bootstrap method and the method using the LPMs. Through numerical experiments on artificial genetic network inference problems, we check the effectiveness of assessing the confidence values of the regulations.
机译:最近,我们提出了一种使用线性规划机(LPM)的遗传网络推断方法。由于该方法通过解决线性规划问题来推断遗传网络,因此其计算时间非常短。但是,通过使用LPM的方法推断出的通用网络通常包含大量错误肯定的规定。当我们尝试将推论方法应用于实际问题时,我们必须通过实验验证推论的规则。因此,减少假阳性法规的数量很重要。为了减少必须验证的法规数量,本研究为所有可能的法规分配了置信度值。为此,我们将引导方法和使用LPM的方法结合在一起。通过对人工遗传网络推断问题的数值实验,我们检查了评估法规置信度的有效性。

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