Fabricaction of nanoparticle-based microneedle for potential drug delivery

摘要

Poly Dimethyl Siloxane (PDMS) microneedle mold having tapered cone tips for a potential nanoparticle-based drug delivery was introduced and investigated. The fabrication of PDMS mold was performed with laser writer, which has great efficiency in repeatability and simplicity. Nanoparticles, such as polystyrene, was drop-casted at the tip of biocompatible polymers of carboxy methylcellulose (CMC) and agarose microneedle. The results demonstrated a high feasibility of successful application to a simple manufacturing of microneedle in addition to a new functionality of the microneedle for the transport of nanoparticle-conjugated drugs.