Characterizing information transmission in cerebellar granule neuron

摘要

At the cellular scale, single-neurons process information mainly through spikes or action potentials [1]. Although the types of synaptic plasticity and the range of times cales over which they operate suggest that synapses have a more active role in information processing, the parameter space still remains unexplored. We used a mathematical model of cerebellar granule cell to explore information transmission in mossy fibre - granule cell synapse of the cerebellum. The impact of plasticity changes in excitatory synaptic release probability and variation in intrinsic excitability of granule cell was studied combining the modulatory effects of inhibition. We explore the changes in pre and post synaptic factors and report their influence on first spike latency and spike amplitude, revealing the indicators of information encoding in individual neurons [2].