Fabrication, surface properties and protein encapsulation/release studies of electrospun gelatin nanofibers

摘要

The composite nanofibrous mats electrospun from a solution consisting of gelatin, Bovine Serum Albumin (BSA, a model compound to simulate proteins), Polyethylene glycol sorbitan monolaurate (Tween-20) and 2,2,2-trifluoroethanol (TFE) was prepared and characterized. The morphologies of the nanofibrous mats were examined by scanning electron microscopy (SEM); the surface hydrophilicity was measured by the water contact angle method; and the protein release profiles from the electrospun nanofibrous mats immersed in phosphate buffered saline (PBS) for various time periods were recorded and analyzed. The results indicated that the composite nanofibrous mat electrospun from the emulsion had the most desired and controllable protein release behaviours and it could be utilized as both a drug/protein encapsulation vehicle and a tissue engineering scaffold.