Development of topical formulation for treatment of tuberculosis

摘要

Tuberculosis is caused by residence of Mycobacteriumtuberculosis in alveolar macrophages of the host. To deliverdirectly to an antitubercular agent to infected alveolarmacrophages with M. Tuberculosis, topical formulation fortreatment of tuberculosis was developed. An antitubercularagent, rifampicin (RFP), was spray dried with PLGA, as acarrier, to formulate with favorable size for pulmonaryadministration. By modifying the surface of formulation, invitro ratio of depositing pulmonary region was improved.When the formulation was administered intratracheally intotuberculosis infected rats, the formulation decreased thetubercle nodules.