Enteric coated micro-particles for targeted and controlled release

摘要

This work is focused on production of enteric coatedmicroparticles for oral administration, using a water-inoil-in water (W1/O/W2) solvent evaporation technique.The active agent theophylline (TP) is encapsulated incellulose acetate phthalate (CAP), a pH-sensitive polymeravailable on the market, which is insoluble in acidicmedia, but dissolves at neutral pH (above pH 6). Somepreliminary tests are carried out using a novel synthesizedpH-sensitive poly(methyl methacrylate-acrylic acid)copolymer, P(MMA-AA), which is checked to replaceCAP in theophylline enteric coated microparticles.