Liposome Surface Modification with pH-Responsive Polyampholytes for the Controlled-release of Drugs

摘要

Ampholytic polymers comprised of 2-(diethylamino)ethyl methacrylate (DEAEMA) and acrylicacid (AA) in varying molar ratios were used to modifyegg yolk phosphatidylcholine (EYPC) liposomespreviously encapsulated with a model drug, pyranine.The modified EYPC liposomes were found to be pHresponsive. The critical pH values at which the pyraninebegan to release from these liposomes at 37 °C wereobserved to decrease with increasing DEAEMA contentin the polymers.