N,N,N-trimethyl chitosan-coated whole inactivated influenza virusvaccine for intranasal administration

摘要

Whole inactivated influenza virus (WIV) was coated withN,N,N-trimethyl chitosan (TMC). TMC-coated WIV(TMC-WIV) was characterized physicochemically andimmunologically in a murine challenge model. The novelTMC-WIV is a positively charged nanoparticulateinfluenza vaccine for intranasal (I.n.) vaccination thatinduces significantly higher hemagglutination inhibitiontiters and antibody titers as well as better protection thanplain WIV vaccine after I.n. Vaccination.