Intracellular ntracellular Metallothionein Delivery to Protect against Hyperglycemia Hyperglycemia-induced Cytotoxicity inDiabetic Complications

摘要

Protein transduction domain (PTD) PTD)-metallothionein etallothionein(MT) fusion proteins were constructed with Tat and 11arginines arginines, and MT. , This study represented strongprotective effects of PTD PTD-MT fusion proteins againstcytotoxi cytotoxicity induced by hyperglycemia andcity glucolipotoxicity in cardiomyocytes and pancreas cells.