Fabrication of Novel Designed AFM Probe Integrated with Microneedle for Cellular Function Analysis

摘要

In order to realize cellular function analysis in a single living cell, we have been developing a newly designed probe for atomic force microscope (AFM), The probe will be capable not only of performing AFM measurements but also of introducing desired biomolecules into living cells and extracting biomolecuks expressed in the cells. In order to realize such an AFM probe, we have been developed the most important techniques for fabricating microneedles with a sharpened tip and a microchannel embedded into a Si cantilever. By employing the developed techniques, the prototype AFM probes were successfully fabricated.