Chitosan-coated PLGA nanoparticles as a flexible and efficient carrier for antisenseoligonucleotides

摘要

Our study aimed to evaluate chitosan-coated PLGA nanoparticles as carriers for DNA/RNA. Varying the process parameters produced nanoparticles whose colloidal characteristics could be tailored according to the payload. MTT/LDH assays revealed the safety of these nanoparticles compared to PEI solution. Particle/oligonucleotide nanoplexes were efficiently internalized by A549 cell lines.