The impact of free or N-(2-hydroxypropyl)methacrylamide (HPMA) bound doxorubicin on surface membraneglycosylation: the possible role of CD43

摘要

Conjugates containing aminolytically bound doxorubicin possess distinct intracellular fate in contrast to free doxorubicin or those with hydrolytically bound doxorubicin. These conjugates affect surface glycosylation of cancer cells both qualitatively and quantitatively, probably due to CD43 expression.