Design and gamma-scintigraphic evaluation of a floating and pulsatile drug delivery system based on an impermeable cylinder

摘要

Using current release technology, it is possible for many drugs oral delivery for a pulsed or pulsatile release, which is defined as the rapid and transient release of a certain amount of molecules within a short time-period immediately after a predetermined off-release period. Floating-pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. The present study focused on development and evaluate of a multifunctional drug delivery system, which was designed as a floating -pulsatile drug delivery system. Such drug delivery system is developed from the pulsatile system described by Krogel and Bodmeier (Fig. 1, case 1). The novel system consists of a drug tablet placed within an impermeable polymeric cylinder closed with an erodible drug-free plug and floating material filled at the bottom (Fig. 1, case2). When in contact with the aqueous fluids, the erodible drug-free plug is responsible for a lag phase preceding the onset of release and the floating material filled at the bottom is responsible for buoyancy properties of the formulation.