Galactosylated chitosan-graft-polyethylenimine as a gene carrier for hepatocyte targeting

摘要

We prepared galactosylated chitosan-graft-polyethylenimine (GC-g-PE!) copolymer by an imine reaction between periodate-oxidized GC and low molecular weight PEL Cytotoxicity and transfection efficiency were checked in this study. Results suggest that GC-g-PEI can be used in gene therapy to improve transfection efficiency and hepatocyte specificity in vitro and in vivo.