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Galactosylated polyethylene glycol-chitosan-graft-spermine copolymer as a hepatocyte targeting gene carrier and gene therapy using the same
Galactosylated polyethylene glycol-chitosan-graft-spermine copolymer as a hepatocyte targeting gene carrier and gene therapy using the same
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机译:半乳糖基化聚乙二醇-壳聚糖-接枝-精胺共聚物作为靶向肝细胞的基因载体,并使用其进行基因治疗
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摘要
PURPOSE: A lactosylated polyethylene glycol-chitosan-g-spermine copolymer is provided to have excellent transduction efficiency of hepatocyte targeting, while having low cytotoxicity. CONSTITUTION: A galactosylated polyethylene glycol-chitosan-graft-spermine copolymer is in chemical formula 1. A manufacturing method of the copolymer comprises a step of synthesizing polyethylene glycol by reacting galactose-containing glycoprotein, and a bifunctional polyethylene glycol; a step of manufacturing a chitosan-graft-spermine copolymer by reacting chitosan and spermine; and a step of reacting the galactosylated polyethylene glycol and the chitosan-graft-spermine copolymer.
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