PEG-Detachable Polyplex Micelles Responding to Reduced Environment Based on PEG-b-Polyasparatamide Catiomers

摘要

Novel smart polyplex micelles based on poly(ethylene glycol)-block-polyasparatamide copolymers containing disulfide linkages (PEG-SS-P[Asp(DET)]) were developed, and their utility as gene carriers was investigated. The PEG-SS-P[Asp(DET)] spontaneously forms a polyplex micelle with plasmid DNA (pDNA), and the PEG chains were detached under the environment.