Slow-Releasing Tranilast in Polytetrafluoroethylene/Polylactide-co-glycolide Laminate Delays Adjustment after Strabismus Surgery in Rabbit Model

摘要

Polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminates containing tranilast were prepared by solvent casting technique for slow-releasing and applied to rabbit model for delayed adjustable strabismus surgery. In vitro release of tranilast was tested and the effect of the laminates on strabismus surgery was evaluated by adjustability, adjustment lengths, the forces required and degrees of adhesions of three groups- the PTFE/PLGA-tranilast group (the P-T group), the PTFE group (the P group) and the control group (group C) for 3 or 5 weeks.