Effect of Drug Properties and Dissolution Medium on the In Vitro Release From Carbomer Matrix Tablets

机译：药物特性和溶解介质对卡波姆基质片剂体外释放的影响

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This study evaluated carbomer as extended-release excipient for various drugs and the effect of medium pH on the release. Drug solubility determined broad ranges of release profiles. The effect of dissolution medium on the release was not major if the drug solubility was pH-independent (no major effect on the matrix).

机译：这项研究评估了卡波姆作为各种药物的缓释赋形剂以及中等pH值对释放的影响。药物溶解度决定了宽范围的释放曲线。如果药物溶解度与pH无关，则溶出介质对释放的影响不是主要的（对基质无重大影响）。

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《Controlled Release Society Annual Meeting and Exposition》|2007年|P.480-481|共2页
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Elena Draaanoiu; Andrew Stansbrey; Nancy Ronsko; Edward Greenberg;
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中图分类生物工程学（生物技术）;
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机译：溶解介质组成对用新型卡波姆聚合物制备的对乙酰氨基酚基质片剂的药物释放和体外/体内相关性的影响。
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4. Effect of Drug Properties and Dissolution Medium on the In Vitro Release From Carbomer Matrix Tablets [C] . Elena Draaanoiu, Andrew Stansbrey, Nancy Ronsko, Controlled Release Society Annual Meeting and Exposition . 2007

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机译：延长释放淀粉乙酸酯基质片剂配方性质与体外溶出行为之间的关系

Effect of Drug Properties and Dissolution Medium on the In Vitro Release From Carbomer Matrix Tablets

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