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Modelling of agglomerate behaviour under shear deformation

机译:剪切变形下凝聚行为的建模

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High shear mixer granulators are typically found in pharmaceutical and detergent industries, and are capable of reducing processing time and producing agglomerates with high strength and density. Generally, several granulation scaling-up stages are involved before reaching the production level. This is conducted to exert better understanding, control and optimisation at the smaller scales before proceeding to the larger scales in terms of geometric, kinematic and/or dynamic similarities. During granulation scaling-up stages, the mechanics of particle interactions and the prevailing level of compressive stresses and strains within the granulator are affected by the variation in hydrodynamics of granulator as a result of different scales. This in turn affects the final structure of the agglomerates. In this paper we analyse the effect of velocity field of two different scales of high shear mixer granulator (1 / and 5 I) on the structure of the evolved agglomerates. The study is based on computer simulation using Distinct Element Method (DEM). A single agglomerate is generated using DEM computer code and is placed in a bed of primary particles. A velocity field is then superimposed on the surrounding particles. This velocity field corresponds to that obtained experimentally from a separate study using Positron Emission Particle Tracking (PEPT) analysis on 1 / and 5 / granulators which were scaled up based on the condition of constant shear stress. The results show that when the velocity profile of 1 / granulator is used the agglomerate becomes more elongated and it has a smaller packing fraction. Therefore the agglomerate would be weaker.
机译:高剪切混合器造粒机通常在制药和洗涤剂行业中发现,并且能够减少加工时间并以高强度和密度产生聚集体。通常,在达到生产水平之前,涉及几个肉芽缩放阶段。在进行几何,运动/或动态相似度方面,在进行较大的尺度之前,进行这一点以在较小的尺度上发挥更好的理解,控制和优化。在造粒缩放阶段期间,由于不同的尺度,颗粒相互作用和造粒机内的压缩应力和菌株的常规水平的影响受到不同的尺度的影响。这反过来影响了附聚物的最终结构。在本文中,我们分析了高剪切混合器造粒机(1 /和5i)的两种不同尺度的速度场对进化附聚物的结构。该研究基于使用不同元素法(DEM)的计算机仿真。使用DEM计算机代码生成单个附聚物,并将其放置在主粒子的床中。然后将速度场叠加在周围的颗粒上。该速度场对应于通过使用正电子发射颗粒跟踪(Pept)分析在基于恒定剪切应力的条件下进行缩放的1 /和5/5/5/5/5/5 /和5个造粒机进行实验获得的。结果表明,当使用1 /造粒机的速度分布时,聚集体变得更细长,并且具有较小的填充级分。因此聚集将较弱。

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