Quantification and Mapping of the Microenvironmental pH in HPMC-based MatrixTablets by Electron Paramagnetic Resonance Imaging

机译：基于电子顺磁共振成像的基于HPMC的MatrixTablet中微环境pH的定量和定位

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Electron Paramagnetic Resonance Imaging(EPRI) was applied to quantify microenvironmentalpH spatially and non-invasively in hydrated HPMCbasedmatrix tablets containing various pHmodifiers. Additionally,we demonstrated thecoherence between the microenvironmental pH anddrug release of the weakly basic drug dipyridamole.

机译：电子顺磁共振成像（EPRI）用于量化微环境基于水合HPMC的空间非侵入式pH 含有各种pH值的基质片剂修饰符。此外，我们展示了微环境pH与弱碱性药物双嘧达莫的药物释放。

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《Annual meeting exposition of the Controlled Release Society》|2005年|1-2|共2页
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S.Hornung; W. Herrmann; B. Lueckel; A. Ries; A. Kramer; R.Gurny;
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中图分类药学;
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Quantification and Mapping of the Microenvironmental pH in HPMC-based MatrixTablets by Electron Paramagnetic Resonance Imaging

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