Computational Evaluation of Controlled Release Oral Delivery for Some Atypical Antipsychotics

机译：某些非典型抗精神病药控释口服给药的计算评价

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We use computational ADME tools, physicalchemical measurements in vitro, and the results of sitespecificgastrointestinal dosing in the rat and dog topredict the effect of controlled release oral delivery onthe plasma concentrations and duration of action of aseries of-carboline atypical antipsychotics.

机译：我们使用物理上的计算ADME工具体外化学测量以及特定部位的结果在大鼠和狗中的胃肠道给药预测控释口服给药对血浆浓度和作用时间系列 -咔啉非典型抗精神病药。

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《Annual meeting exposition of the Controlled Release Society》|2005年|1-2|共2页
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GM Eichenbaum; VA Nguyen; WW van Osdol;
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中图分类药学;
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入库时间 2022-08-26 14:53:54

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1. Preclinical assessment of the feasibility of applying controlled release oral drug delivery to a lead series of atypical antipsychotics. [J] . Eichenbaum G, Pollock Dove C, Nguyen J, Journal of pharmaceutical sciences. . 2006,第4期

机译：临床前评估将控释口服药物递送应用于一系列非典型抗精神病药的可行性。
2. A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of osmotic-controlled release oral delivery system methylphenidate HCl in adults with attention-deficit/hyperactivity disorder in Japan [J] . TakahashiN., KohT., TominagaY., The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry . 2014,第5a6期

机译：一项随机，双盲，安慰剂对照，平行组研究，以评估渗透控制释放口服给药系统哌醋甲酯盐酸盐在患有注意力不足/多动症的成年人中的疗效和安全性
3. Paliperidone-ER: first atypical antipsychotic with oral extended release formulation [J] . Marion Lautenschlager and Andreas Heinz Expert Review of Neurotherapeutics . 2008,第2期

机译：Paliperidone-ER：首次口服缓释制剂的非典型抗精神病药
4. Oral delivery using a novel controlled release technology: system design and materials selection [C] . G.Kupperblatt, A.Katdare, G.Slack, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：使用新型控释技术的口服给药：系统设计和材料选择
5. Novel formulation approaches in the design strategy, development and evaluation of oral controlled release drug delivery systems. [D] . Pillay, Viness. 2000

机译：口服控释药物递送系统的设计策略，开发和评估中的新颖配方方法。
6. Changing the Drug Delivery System: Does it Add to Non-Compliance Ramifications Control? A Simulation Study on the Pharmacokinetics and Pharmacodynamics of Atypical Antipsychotic Drug [O] . Mohammed H. Elkomy 2020

机译：更改药物输送系统：是否增加了不合规后果控制？非典型抗精神病药的药代动力学和药效学模拟研究
7. Efficacy and safety of oral atypical antipsychotics for schizophrenia : a meta-analysis including paliperidone extended-release [O] . Jones, M. P, Nicholl, D, Trakas, K 2008

机译：口服非典型抗精神病药治疗精神分裂症的疗效和安全性：荟萃分析，包括帕潘立酮缓释

Computational Evaluation of Controlled Release Oral Delivery for Some Atypical Antipsychotics

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