EGF-Conjugated Poly(ethylene glycol)-block-Poly( -valerolactone) Micelles as a Delivery System for Active Targetingof Hydrophobic Anticancer Agents

摘要

Epidermal growth factor (EGF) conjugatedpoly(ethylene glycol)-b-poly(δ-valerolactone) wassynthesized and used to prepare a delivery vehicle foractive targeting to cancers wherein the EGF receptor(EGFR) is overexpressed. The EGF-conjugated deliverysystem was demonstrated to undergo enhanced uptake inEGFR-overexpressed cells.