A Pharmacokinetic and Tissue Distribution Study of a Palladium Labeled MicroparticleFormulation (Pd-AI-700)Following Intravenous Administration in Rats

摘要

Pharmacokinetics and tissuedistribution of [Pd]-AI-700 were determinedfollowing intravenous administration in rats.Pd was cleared from blood with a ca. 50-85% decline in concentration during a fiveminute interval immediately post-dose. At1440 minutes post-dose, 52 to 72% of thedose was recovered from organs of thereticuloendothelial system.