NITRIC OXIDE LEVEL ASSOCIATED WITH GASEOUS FORMALDEHYDE EXPOSURE IN LUNGS OF MICE

摘要

To explore ifthe NOS level in airway is associated with air formaldehyde. In this study 24 male Kun Ming mice were divided into 4 exposure groups (0 mg/m3, 0.5 mg/m3, 1.0 mg/m3, 3.0 mg/m3) for 72h continuously. After exposure the NOS activities and the NO detection rate in lungs of mice were measured with reagent kits. The results showed that along with the formaldehyde ascension the NOS activities were restrained at first and then improved significantly (P＜0.05), while the NO detection rate showed the similar regulation. We suggest that formaldehyde play dual effects in vivo: at a low formaldehyde exposure (≤0.5mg/m3), the NOS activities in lungs is restrained. However, the repeated high formaldehyde exposure would alter the VR1 mRNA expression levels in the lung of mice, then the NOS activities shall be increased and the NO concentration in airway will also be ascended.