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EFFECT OF D,L-POLYLACTIC ACID (D,L-PLA) ON PHYSICOCHEMICAL CHARACTERISTICS AND PHARMACOKINETICS OF PACLITAXEL-CONTAINING POLY(ETHYLENE OXIDE)-POLY(LACTIC ACID) (mPEG-PLA) POLYMERIC MICELLES

机译：D，L-聚乳酸（D，L-PLA）对含多环氧化物的聚环氧乙烷-乳酸（mPEG-PLA）聚合物胶束的物理化学特性和药代动力学的影响

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In this study, we have evaluated the effect of D,L-PLA on physicochemical characteristics and pharmacokinetics of paclitaxel-containing polymeric micelles of mPEG-PLA (PM). D,L-PLA was incorporated into mPEG-PLA micelles with paclitaxel to control the micellar size and also improved the stability of mPEG-PLA micelles. It increased the residence time of drug in blood circulation.

机译：在这项研究中，我们评估了D，L-PLA对含紫杉醇的mPEG-PLA（PM）聚合物胶束的理化特性和药代动力学的影响。用紫杉醇将D，L-PLA掺入mPEG-PLA胶束中，以控制胶束的大小，并改善了mPEG-PLA胶束的稳定性。它增加了药物在血液循环中的停留时间。

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《Proceedings of the 29th Annual Meeting of the Controlled Release Society》|2002年|p.1252-1253|共2页
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作者
S. Lee; M. Hyun; J. Yu; D. Jang; B. Kim; M. Seo; H. Oh;
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正文语种
中图分类化学工业;
关键词
polymeric micelles; poly(lactic acid); poorly soluble drugs;

机译：高分子胶束;聚乳酸;难溶性药物;

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1. Pharmacokinetic study of 3-in-1 poly(ethylene glycol)-block-poly(D, L-lactic acid) micelles carrying paclitaxel, 17-allylamino-17- demethoxygeldanamycin, and rapamycin (Conference Paper) [J] . Shin H.-C., Cho H., Lai T.C., Journal of Controlled Release: Official Journal of the Controlled Release Society . 2012,第1期

机译：携带紫杉醇，17-烯丙基氨基-17-脱甲氧基格尔德霉素和雷帕霉素的3合1聚（乙二醇）-嵌段-聚（D，L-乳酸）胶束的药代动力学研究（会议论文）
2. Vorinostat with sustained exposure and high solubility in poly(ethylene glycol)-b-poly(dl-lactic acid) micelle nanocarriers: Characterization and effects on pharmacokinetics in rat serum and urine [J] . MohamedE.A., ZhaoY., MeshaliM.M., Journal of pharmaceutical sciences. . 2012,第10期

机译：在聚乙二醇-b-聚（dl-乳酸）胶束纳米载体中具有持续暴露和高溶解度的伏立诺他：在大鼠血清和尿液中的表征及其对药代动力学的影响
3. In-vitro cytotoxicity and combination effects of the docetaxel-conjugated and doxorubicin-conjugated poly(lactic acid)-poly(ethylene glycol)-folate-based polymeric micelles in human ovarian cancer cells [J] . Hami Zahra, Rezayat Seyed Mahdi, Gilani Kambiz, Journal of Pharmacy and Pharmacology . 2017,第2期

机译：多西紫杉醇缀合和多柔比蛋白 - 缀合的聚（乳酸） - 聚（乙二醇） - 卵巢蛋白癌细胞的聚合物胶束的体外细胞毒性和组合效应
4. EFFECT OF D,L-POLYLACTIC ACID (D,L-PLA) ON PHYSICOCHEMICAL CHARACTERISTICS AND PHARMACOKINETICS OF PACLITAXEL-CONTAINING POLY(ETHYLENE OXIDE)-POLY(LACTIC ACID) (mPEG-PLA) POLYMERIC MICELLES [C] . S. Lee, M. Hyun, J. Yu, Annual meeting of the Controlled Release Society . 2002

机译：D，L-聚乳酸（D，L-PLA）对含紫杉醇聚（环氧乙烷） - 磷酸（乳酸）（MPEG-PLA）聚合物胶束的物理化学特性和药代动力学的影响
5. Synthesis and Characterization of Silicate Ester Prodrugs and Poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) Block Copolymers for Formulation into Prodrug-Loaded Nanoparticles. [D] . Wohl, Adam Richard. 2012

机译：硅酸酯酯前药和聚（乙二醇）-b-聚（乳酸-共-乙醇酸）嵌段共聚物的合成和表征，用于配制成载有前药的纳米颗粒。
6. Pharmacokinetics of Quercetin-Loaded Methoxy Poly(ethylene glycol)-b-poly(L-lactic acid) Micelle after Oral Administration in Rats [O] . Li Lv, Chunxia Liu, Zhengrong Li, 2006

机译：口服槲皮素的甲氧基聚（乙二醇）-b-聚（L-乳酸）胶束的药代动力学
7. Pharmacokinetic study of 3-in-1 poly(ethylene glycol)-block-poly(D, L-lactic acid) micelles carrying paclitaxel, 17-allylamino-17-demethoxygeldanamycin, and rapamycin [O] . Ho-Chul Shin, Hyunah Cho, Tsz Chung Lai, 2012

机译：3合 - 1聚（乙二醇） - 伯-polock-poly（D，L-乳酸）胶束携带紫杉醇，17- allylamino-17-脱氧糖醛霉素和雷帕霉素的药代动力学研究

EFFECT OF D,L-POLYLACTIC ACID (D,L-PLA) ON PHYSICOCHEMICAL CHARACTERISTICS AND PHARMACOKINETICS OF PACLITAXEL-CONTAINING POLY(ETHYLENE OXIDE)-POLY(LACTIC ACID) (mPEG-PLA) POLYMERIC MICELLES

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