IMMUNE TOLERANCE INDUCED BY POLYETHYELEN GLYCOL-CONJUGATE OF PROTEIN ANTIGEN

机译：聚乙二醇肽结合蛋白抗原诱导的免疫耐受

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The mechanism of immune tolerance induced by PEG-protein antigens has been unknown. By using transgenic mice with the T cell receptor genes, we demonstrated that immune tolerance induced by PEG-protein antigen is at least in part mediated by the central tolerance of antigen-specific Th cells in the thymus.

机译：PEG蛋白抗原诱导的免疫耐受机制尚不清楚。通过使用具有T细胞受体基因的转基因小鼠，我们证明了PEG-蛋白抗原诱导的免疫耐受至少部分由胸腺中抗原特异性Th细胞的中央耐受介导。

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《Proceedings of the 29th Annual Meeting of the Controlled Release Society》|2002年|p.345-346|共2页
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作者
Hiroyuki Nishimura; Tetsuya Saito; Yo Kodera; Misao Hiroto; Ayako Matsushima; Yuji Inada;
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正文语种
中图分类化学工业;
关键词
immunogenicity; polyethylene glycol; PEGylation;

机译：免疫原性;聚乙二醇;聚乙二醇化;

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专利

1. Peripheral tolerance of antigen-specific Th cells induced with polyethylene glycol-conjugate of protein antigen [J] . Masaomi Obata, Takuma Fujii, Mareki Ohtsuji, Open Journal of Immunology . 2013,第2期

机译：聚乙二醇结合蛋白抗原诱导的抗原特异性Th细胞的外周耐受性
2. Autoimmunity and the microbiome: T-cell receptor mimicry of "self" and microbial antigens mediates self tolerance in holobionts: The concepts of "holoimmunity" (TcR-mediated tolerance for the holobiont) and "holoautoimmunity" (loss of tolerance for the holobiont) are introduced [J] . Root-Bernstein Robert BioEssays : . 2016,第11期

机译：自身免疫和微生物组：“自我”和微生物抗原的T细胞受体模拟介导了整体生物的自我耐受性：“整体免疫”（TcR对整体生物的耐受性）和“整体自身免疫”（整体生物的耐受性丧失）的概念介绍
3. Antigen-specific tolerance to self-antigens in protein replacement therapy, gene therapy and autoimmunity [J] . Steinman Lawrence, Ho Peggy P., Robinson William H., Current opinion in immunology . 2019,第期

机译：抗原特异性对蛋白质替代疗法，基因治疗和自身免疫的自我抗原的耐受性
4. IMMUNE TOLERANCE INDUCED BY POLYETHYELEN GLYCOL-CONJUGATE OF PROTEIN ANTIGEN [C] . Hiroyuki Nishimura, Tetsuya Saito, Yo Kodera, Annual meeting of the Controlled Release Society . 2002

机译：蛋白质抗原的聚乙醇乙二醇缀合物诱导的免疫耐受性
5. Local Administration of Biomaterials for Inducing Antigen-Specific Immune Tolerance [D] . Li, Yuan-Ping Peter. 2021

机译：局部施用生物材料，用于诱导抗原特异性免疫耐受性
6. Taming autoimmunity: Translating antigen-specific approaches to induce immune tolerance [O] . José M. Carballido, Pere Santamaria 2019

机译：驯服自身免疫：翻译抗原特异性方法以诱导免疫耐受
7. Peripheral tolerance of antigen-specific Th cells induced with polyethylene glycol-conjugate of protein antigen [O] . Masaomi Obata, Takuma Fujii, Mareki Ohtsuji, 2013

机译：聚乙二醇偶联的蛋白抗原诱导的抗原特异性Th细胞的外周耐受

IMMUNE TOLERANCE INDUCED BY POLYETHYELEN GLYCOL-CONJUGATE OF PROTEIN ANTIGEN

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