Susceptibility on hearing of workers for noiseexposure and mitochondrial dna 7.4 KB deletion

摘要

Purpose: To explore the association between susceptibility of hearing for noise exposure and mitochondrial DNA (mtDNA) deletion. Subjects and Methods: The DNA was collected from white blood cells of 41 workers. Twenty one of them were susceptibility on hearing to long-term noise exposure and the other twenty were not susceptibility. An advanced PCR technique was applied to observe the 7.4kb mtDNA deletion. Results: Four kinds of deletion were found from 3.1kb to 7.4kb in these workers. The 7.4kb deletion frequency in susceptibility group (10/21) was significantly higher than that in control group (3/20), OR=5, P<0.05. Conclusion: This result suggests that the 7.4kb mtDNA deletion is one of possible risk factors for individual susceptibility on hearing to noise exposure.