The Heat Is on in Cancer

摘要

The hallmarks of hyperthermia and its pleotropic effects are in favour of its combined use with chemotherapy and/or radiotherapy.. Preclinical research reveals that for heat killing and synergistic effects the thermal dose is most critical. Thermal enhancement of drug cytotoxicity is accompanied by cellular death and necrosis without increasing its oncogenic potential. The induction of genetically defined stress responses can deliver danger signals to activate the host's immune system.