My contribution aims to introduce the distinction, not previously analyzed, between two kinds of abduction, theoretical and manipulative, in order to provide an integrated framework to explain some of the main aspects of both creative and model-based reasoning effects engendered by the practice of science. The distinction appears to be extremely convenient: creativity will be viewed as the result of the highest cases of theoretical abduction showing the role of the so-called model-based abduction. Moreover, I will delineate the first features of what I call manipulative abduction showing how we can find methods of constructivity at the experimetnal stage, where the recent episte-mological tradition has settle the most negative effects of theory-ladenness.
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