Complexity changes in instantaneous heart rate prior to ventricularfibrillation in patients with implantable defibrillator

摘要

The objective of this study was to determine complexity changes ofinstantaneous heart rate prior to malignant tachy-arrhythmic events. Arethese possible changes detectable by means of an implantabledefibrillator? R-R intervals of the internal defibrillator memory wereanalyzed by means of linear and non-linear techniques. The non-linearanalysis revealed a significant decline of the slope of the correlationintegral prior to the malignant tachycardia. In contrast, the linearparameter standard deviation of the R-R series, a measure of heart ratevariability, did not show any significant change. Thus methods of earlydetection of vulnerable periods and possible new strategies inprevention of malignant events with implantable anti-tachy-arrhythmicdevices may benefit from non-linear analysis of R-R intervals