Studying Solid – Liquid Interfaces Using The Quartz Crystal Microbalance/Heat ConductionCalorimeter

摘要

Processes at the solid – liquid interface play an important role in many biochemical and physicalphenomena. Studying the thermodynamics and the kinetics of those processes helps in drugdevelopment, in the development and use of special coatings, and more. In this work we use QuartzCrystal Microbalance/Heat Conduction Calorimetry (QCM/HCC) in order to obtain information aboutbiochemical processes at the solid liquid interface. Two systems studied are discussed- the binding ofhuman serum albumin (HAS) with the drug warfarin, and the esterification of a self assembledmonolayer of 11- Mercaptoundecanoic acid. In both cases we show the it is possible to follow thereaction in real time and to determine both the rate constant and the reaction enthalpy by using theQCM/HCC technique.