Self-Diffusion of PEO-Modified Paclitaxel in Aqueous Solution: Hydrodynamic Properties

摘要

The anti-cancer drug Paclitaxel has been hydrophilized by coupling with poly(ethylene oxide) through a self-immolating linker to the polymer. The mobility of the functionalized polymer and of the amphiphilic drug-modified polymer in D_2O was studied by the temperature and concentration dependence of the long-time self-diffusion coefficients of the components. The technique applied was pulse-gradient field NMR spectroscopy. The diffusivity of the molecules can be described in terms of the Einstein-Sutherland and the Stokes-Einstein equations. First results indicate that combining the drug with the polymer rather influences the rigidity parameter and the pair-interaction in solution than the shape and the hydrodynamic radius of the polymer coil. Unexpectedly, micelle-formation, although highly probable, was not observed within the concentration range investigated here.