Novel algorithm to determine absorption and scattering coefficients from time-resolved measurements

摘要

Abstract: A novel algorithm is demonstrated to determine the reduced scattering and absorption coefficients from time-resolved reflectance measurements at two positions on the surface of biotissue. The algorithm is very straightforward and fast, in which only some simple mathematical operations are involved, avoiding complicated iterative non-linear fitting to the time- resolved curve. The derived reduced scattering coefficient is not affected by whatever boundary condition is applied. The algorithm was verified using the time-resolved data from the Monte-Carlo model. Both the semi-infinite medium and the turbid slab medium were tested. In contrast to the non-linear fitting method, it is found using this algorithm that both the scattering and absorption coefficients can be determined to a high accuracy. !10