One Pot Synthesis of N-Phosphonamidothionate Derivatives

摘要

In this paper a convenient and efficient approach to one-pot synthesis of N-phosphonamidothionate derivatives under mild conditions had been developed. In the first step only one chloride of O-isopropyl phosphorodichloridothioate is displaced by amino acid ester to form a new phosphorus-nitrogen bond. The biological-activities of these compounds have been investigated further currently.