Associations between Traffic-Related Air Pollution and Cardiovascular Disease Risk Factors Were Stronger in More Walkable Neighborhoods: The Cardiovascular Health in Ambulatory Care Research Team (CANHEART) Cohort

摘要

Introduction Studies suggest living in a more walkable neighborhood may protect against cardiovascular disease risk factors such as hypertension (HTN) and diabetes mellitus (DM) by encouraging physical activity. Walkable neighborhoods, however, often carry higher levels of traffic-related air pollution. Little is known regarding whether synergistic effects may exist between walkability and air pollution on these risk factors. Hypothesis We hypothesized that the association between traffic-related air pollution, hypertension, and diabetes mellitus would be stronger in more walkable areas. Methods We drew a cross-sectional sample of individuals ages 40-74 on January 1, 2008 from the CANHEART cohort. HTN and DM were ascertained using validated algorithms. Walkability (quintiles, Q5 highest, Ql lowest) was measured using a validated index which has previously been shown to be inversely associated with obesity and diabetes. Exposure to nitrogen dioxide, a valid marker for traffic-related air pollution, was assessed using a land use regression models. The associations were tested using logistic regression with cluster-robust standard errors, adjusting for age, sex, area-level income, ethnicity, and comorbidities. Results 2,618,584 individuals were included in the analysis. Walkability was inversely associated with odds for HTN (Q5 vs. Ql OR = 0.80, 95% CI: 0.79, 0.82) and DM (Q5 vs. Q1 OR = 0.89, 95% CI: 0.87, 0.91), while N02 was positively associated with each (HTN: OR = 1.02 per 10 ppb (1.01, 1.03); DM: OR = 1.11 per 10 ppb (1.09,1.13)). We observed significant interactions between walkability and N02 on odds for HTN and DM, with stronger NO2 associations in the most walkable neighborhoods. Conclusions We observed significant interactions between traffic-related air pollution and walkability on odds for HTN and DM. This finding suggests that benefits from living in more walkable neighborhoods may be partially offset by stronger negative associations with air pollution.