BIS-OXAZOLINES AS EFFECTIVE LIGANDS FOR PALLADIUM-CATALYZED COUPLING AND CARBONYLATION REACTIONS

摘要

The synthesis and characterization of new bis (oxazoline) (BOX) ligands and their corresponding palladium complexes (Pd-BOX) was achieved. The catalytic activities of these new complexes were tested in Suzuki-Miyaura, Heck, and Sonogashira coupling reactions and in carbonylation reactions. Palladium-BOX complexes showed very high catalytic activities towards the coupling reactions with different aryl halides, aryl boronic acids, alkenes and alkynes and for the regioselective alkoxycarbonylation of alkynes. Various biaryls, substituted alkenes and alkynes, and unsaturated esters were produced in high yields and regioselectivity. The authors would like to acknowledge the support provided by King Abdulaziz City for Science and Technology (KACST) through the Science & Technology Unit at King Fahd University of Petroleum & Minerals (KFUPM) for funding this work through project No. 11-PET1665-04 as part of the National Science, Technology and Innovation Plan.