DELOS~(~R) PROCESS: CRYSTALLIZATION OF PURE POLYMORPHIC PHASES FROM CO_2-EXPANDED SOLUTIONS

摘要

The DELOS~(~R) process is a crystallization method for the straightforward production of nano and micron sized particles of organic compounds with a narrow size distribution. The driving force of this crystallization method is the high, rapid and extremely homogeneous temperature decrease experimented by a CO_2-expanded solution of the compound to crystallize when it is depressurized to atmospheric pressure. In the present work we show the influence of the DELOS~(~R) crystallization conditions over the polymorphic nature and purity of crystalline solids produced.