SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE-BRANCHED POLYETHYLENIMINE MAGNETOPLEXES FOR GENE TRANSFECTION

摘要

@@Emergence of gene therapy provides a highly versatile and potent armor in combating various human diseases (1). Irrespective of the vector types, efficient gene transfection demands appreciable concentration of efficient cell-binding delivery vectors at the target site at the onset of gene delivery. Therefore it is necessary to develop simple, fast and efficient methods or strategies which can expedite the accumulation of the therapeutic cargo on the surface of the target cells and can be remotely controlled by physical means, particularly in in vivo systemic administrations. Among various physical methods, magnet-assisted transfection (2, 3) utilizing magnetic nanoparticles has gained considerable attention due to the promising efficiency, non-toxicity of these magnetic particles and simple experimental needs.