A new concept for preparing drug-delivery-system (DDS) of inhaled drug

摘要

Uptake of medicine by inhalation is the unique, convenient and effective way for the application of apoprotein and DNA biomedicines, by which protecting biomedicines from the decomposition of digestion and the primary hepatic metabolism. Meanwhile, due to the individualities cannot be kept in the absence of dispersing solvent, the nano particles lose the merit, i.e. nano size, when used as inhaled drug. Therefore, in this presentation, we postulated a new concept for preparing the nano inhaled drug and its DDS device, namely, preparing the nano drug particles and simultaneously dispersing them from aggregation by using the nanofiber. As a model of this concept, poly(vinyl pyrrolidone) (PVP) was selected to prepare the crosslinked nanofiber mat while the biomimic antioxidant drug, Ebselen and an amino-acid, Creatine were used as the model drug. The nanofiber having sea-grape-like structure of PVP/Creatine was prepared, and its property of releasing drug by in the passing-through air flow was tested.