POLYMERIZABLE FAB' ANTIBODY FRAGMENT TARGETED HPMA COPOLYMER-MESOCHLORIN E_6 CONJUGATE: BIODISTRIBUTION AND ANTITUMOR ACTIVITY

机译：可聚合FAB抗体片段靶向HPMA共聚物-间氯三叶草E_6共轭物：生物分布和抗肿瘤活性

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The biodistribution and antitumor activity of polymerizable Fab' antibody fragment (MA-Fab') targeted HPMA copolymer-mesochlorin e_6 (Mce_6) conjugate were evaluated in nude mice bearing OVCAR-3 human ovarian carcinoma xenografts. The conjugates exhibited higher accumulation in tumor tissue and higher activity in inhibition of tumor growth than the non-targeted conjugate.

机译：在携带OVCAR-3人卵巢癌异种移植物的裸鼠中，评估了靶向HPMA共聚物-中二氯霉素e_6（Mce_6）缀合物的可聚合Fab'抗体片段（MA-Fab'）的生物分布和抗肿瘤活性。与非靶向缀合物相比，缀合物在肿瘤组织中表现出更高的积累和在抑制肿瘤生长方面更高的活性。

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来源
《International symposium on controlled release of bioactive materials;Consumer diversified products conference》|2001年|p.1283-1284|共2页
会议地点 San Diego CA(US);San Diego CA(US)
作者
Z.-R. Lu; J.-G. Shiah; P. Kopeckova; J. Kopecek;
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Department of Pharmaceutics and Pharmaceutical Chemistry/CCCD;

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关键词
polymerizable Fab'; HPMA copolymer; targeted delivery; anticancer agent; antibody; mesochlorin e_6;

机译：可聚合的Fab'； HPMA共聚物；有针对性的交付；抗癌剂抗体;中氯e_6;

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专利

1. In vitro cytotoxicity, in vivo biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates. [J] . Yuan F, Qin X, Zhou D, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2008,第3期

机译：HPMA共聚物-5-氟尿嘧啶结合物的体外细胞毒性，体内生物分布和抗肿瘤活性。
2. Star Structure of Antibody-Targeted HPMA Copolymer-Bound Doxorubicin: A Novel Type of Polymeric Conjugate for Targeted Drug Delivery with Potent antitumor Effect [J] . Marek Kovar, Jiri Strohalm, Tomas Etrych, Bioconjugate Chemistry . 2002,第2期

机译：抗体靶向的HPMA共聚物结合的阿霉素的星形结构：一种新型的聚合物共轭物，具有靶向药物的有效抗肿瘤作用。
3. Combination chemotherapy and photodynamic therapy with Fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells [J] . HongrapipatJ., Kope?kováP., LiuJ., Molecular pharmaceutics . 2008,第5期

机译：Fab'片段靶向HPMA共聚物结合物联合化疗和光动力疗法治疗人卵巢癌细胞
4. Biodistribution in tumor bearing mice of free and hpma copolymer-bound meso-chlorin e_6 and adriamycin [C] . J.-G. Shiah, Y. Sun, P. Kopeckova, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 1998

机译：游离和hpma共聚物结合的中二氢卟酚e_6和阿霉素在荷瘤小鼠中的生物分布
5. The Use of HPMA Copolymer Conjugates for the Intracellular Targeting of Anticancer Drugs [D] . Callahan, Jon Doyle. 2017

机译：HPMA共聚物结合物用于抗癌药物的细胞内靶向
6. Combination Chemotherapy and Photodynamic Therapy with Fab′ Fragment Targeted HPMA Copolymer Conjugates in Human Ovarian Carcinoma Cells [O] . Jarunee Hongrapipat, Pavla Kopečková, Jihua Liu, -1

机译：Fab片段靶向的HPMA共聚物在人卵巢癌细胞中的联合化学疗法和光动力疗法。
7. Combination Chemotherapy and Photodynamic Therapy with Fab′ Fragment Targeted HPMA Copolymer Conjugates in Human Ovarian Carcinoma Cells [O] . Hongrapipat, Jarunee, Kopečková, Pavla, Liu, Jihua, 2008

机译：Fab'片段靶向的HPMA共聚物在人卵巢癌细胞中的联合化学疗法和光动力疗法。

POLYMERIZABLE FAB' ANTIBODY FRAGMENT TARGETED HPMA COPOLYMER-MESOCHLORIN E_6 CONJUGATE: BIODISTRIBUTION AND ANTITUMOR ACTIVITY

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