Comparing 3D Genome Organization in Multiple Species Using Phylo-HMRF

摘要

Recent developments in whole-genome mapping approaches for the chromatin interactome (such as Hi-C) have facilitated the identification of genome-wide three-dimensional (3D) chromatin organizations comprehensively, and offered new insights into 3D genome architecture. However, our knowledge of the evolutionary patterns of 3D genome structures in mammalian species remains surprisingly limited. In particular, there are no existing phylogenetic-model based methods to analyze chromatin interactions as continuous features across different species to uncover evolutionary patterns of 3D genome organization.