A Relevance Vector Machine Technique for Automatic Detection of Clustered Microcalcifications

摘要

Microcalcification (MC) clusters in mammograms can be important early signs of breast cancer in women. Accurate detection of MC clusters is an important but challenging problem. In this paper, we propose the use of a recently developed machine learning technique - relevance vector machine (RVM) - for automatic detection of MCs in digitized mammograms. RVM is based on Bayesian estimation theory, and as a feature it can yield a decision function that depends on only a very small number of so-called relevance vectors. We formulate MC detection as a supervised-learning problem, and use RVM to classify if an MC object is present or not at each location in a mammogram image. MC clusters are then identified by grouping the detected MC objects. The proposed method is tested using a database of 141 clinical mammograms, and compared with a support vector machine (SVM) classifier which we developed previously. The detection performance is evaluated using the free-response receiver operating characteristic (FROC) curves. It is demonstrated that the RVM classifier matches closely with the SVM classifier in detection performance, and does so with a much sparser kernel representation than the SVM classifier. Consequently, the RVM classifier greatly reduces the computational complexity, making it more suitable for real-time processing of MC clusters in mammograms.