In Situ Monitoring of Cell Adhesion on Thermally Responsive Nanofiber Coatings Using Quartz Crystal Microbalance

摘要

Thermally responsive nanofiber using N-isopropylacrylamide (NIPAAm) fabricated by electrospinning on quartz crystal microbalance (QCM). The wettability was changed according to the temperature that the nanofiber became hydrophobic at temperature above lower critical solution temperature (LCST) and hydrophilic below LCST. Since QCM can detect a mass change by frequency shift, cell adhesion behavior can be quantified by changing temperature. This technique can be applied to micro sensing of malignant cells and early discovery and treatment of any disease.