Experimental study and numerical simulation of laser ablation in the nasopharyngeal tissue of rabbit

摘要

The purpose of this study was to determine the ablation threshold of 1341nm Nd:YAP laser radiation on the nasopharyngeal tissue of rabbit. The laser power of irradiation on the tissue surface was varied from 5 to 12W, while the duration of the irradiation was from 1.0 to 2.5s in 0.5s by increments. With the Nd:YAP laser, the ablation threshold was found in the energy density range among 8.0x10~3 - 9.5x10~3 J/cm~2 and the average diameter of ablation groove was about 0.3mm. Based on the experimental results, a heat transfer model including a phase change process is fitted with the structure of the nasopharyngeal tissue of rabbit. By the photothermal parameters of the nasopharyngeal tissue of rabbit, the energy distribution induced by laser irradiation in tissue is mapped by numerical simulation method and compared with the experimental results.