Switch Detection in Genetic Regulatory Networks

摘要

This paper considers piecewise affine models of genetic regulatory networks and focuses on the problem of detecting switches among different modes of operation in gene expression data. This task constitutes the first step of a procedure for the complete identification of the network. We propose two methods and illustrate the application to the reconstruction of switching times in data produced by a piecewise affine model of the network regulating the carbon starvation response in Escherichia coli.