New Entropy-Based Measures of Gene Significance and Epistasis

摘要

A new framework to formulate and quantify the epistasis of a problem is proposed. It is based on Shannon's information theory. With the framework, we suggest three epistasis-related measures: gene significance, gene epistasis, and problem epistasis. The measures are believed to be helpful to investigate both the individual epistasis of a gene group and the overall epistasis that a problem has. The experimental results on various well-known problems support it.