The stability study of Nifeviroc-loaded microemulsions

摘要

The objective is to study the stability of Nifeviroc-loaded microemulsions (Nifeviroc-MEs).The dilution stability of Nifeviroc-MEs with different loading capacity (0.1％,0.2％,0.3％) was tested by change of mean size,pH and appearance.The centrifugal stability was evaluated by comparing the mean size of Nifeviroc-MEs and dilutions before and after high-speed centrifugation for 30,60,120 min at 10000 rpm.The storage stability was evaluated by the change of appearance,the mean size,PDI and the retention rate of Nifeviroc in the ME.The pH,appearance,size analysis and retention rate results showed the Nifeviroc-MEs had good dilution,centrifugal stability and good storage stability without light.